Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.46 |
| ▸ | CNR2 | P34972 | 5/20 | 0.43 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879239 | 1.00 | MCHR1 (0.46) | MCHR1CNR2CNR1ADRA2AHRH1 | |
| SCHEMBL6872974 | 0.91 | MCHR1 (0.46) | MCHR1CNR2CNR1ADRA2AHRH1 | |
| SCHEMBL6872971 | 0.91 | MCHR1 (0.46) | MCHR1CNR2CNR1ADRA2AHRH1 | |
| SCHEMBL6458733 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458724 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874959 | 0.87 | MCHR1 (0.46) | MCHR1CNR2CNR1ADRA2AHRH1 | |
| SCHEMBL6873378 | 0.83 | GAA (0.54) | MCHR1CNR1ADRA2AHRH1HTR2B | |
| SCHEMBL6873370 | 0.83 | GAA (0.54) | MCHR1CNR1ADRA2AHRH1HTR2B | |
| SCHEMBL6874037 | 0.83 | AURKA (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874044 | 0.83 | AURKA (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |