Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107830 | 0.85 | ALDH1A1 (0.44) | POLBMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL5217967 | 0.84 | KMT2A (0.42) | POLBMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL687471 | 0.81 | POLB (0.47) | POLBMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL2989161 | 0.80 | CYP1A2 (0.47) | POLBKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7113819 | 0.78 | MAPT (0.37) | POLBMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL13480579 | 0.78 | POLB (0.68) | POLBMAPK1KMT2AMEN1KDM4E | |
| SCHEMBL7110018 | 0.78 | PDE3B (0.36) | TSHRLMNA | |
| SCHEMBL1901639 | 0.77 | KDM4E (0.52) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL27678713 | 0.77 | GAA (0.41) | POLBKMT2AMEN1KDM4ENPC1 | |
| SCHEMBL1355211 | 0.73 | KMT2A (0.52) | KMT2AMEN1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667966-B1 | N-ALKYLATED DIAMINOPROPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2012-02-29 | — | — | EP | disclosed |