Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874264 | 1.00 | MAPT (0.42) | MAPTKMT2APOLBHTTMEN1 | |
| SCHEMBL6458231 | 0.90 | KMT2A (0.54) | KMT2AHTTMEN1CYP2D6MCHR1 | |
| SCHEMBL6458135 | 0.90 | MCHR1 (0.40) | MCHR1ADRA2AALOX12HTR1AADRA1A | |
| SCHEMBL6458127 | 0.90 | MCHR1 (0.40) | MCHR1ADRA2AALOX12HTR1AADRA1A | |
| SCHEMBL6458222 | 0.90 | KMT2A (0.54) | KMT2AHTTMEN1CYP2D6MCHR1 | |
| SCHEMBL6866519 | 0.89 | GAA (0.45) | MAPTKMT2APOLBHTTMEN1 | |
| SCHEMBL6866523 | 0.89 | GAA (0.45) | MAPTKMT2APOLBHTTMEN1 | |
| SCHEMBL6878068 | 0.88 | ALOX12 (0.44) | MAPTMCHR1ADRA2AALDH1A1LMNA | |
| SCHEMBL6878065 | 0.88 | ALOX12 (0.44) | MAPTMCHR1ADRA2AALDH1A1LMNA | |
| SCHEMBL6877751 | 0.87 | MCHR1 (0.46) | KMT2AHTTMEN1MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |