Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.35 |
| ▸ | HRH1 | P35367 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874409 | 1.00 | P2RX4 (0.41) | P2RX4P2RX7NPC1RAB9ALMNA | |
| SCHEMBL6874404 | 0.89 | MCHR1 (0.40) | P2RX4P2RX7NPC1RAB9AMCHR1 | |
| SCHEMBL6874408 | 0.89 | MCHR1 (0.40) | P2RX4P2RX7NPC1RAB9AMCHR1 | |
| SCHEMBL6877735 | 0.88 | MCHR1 (0.41) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6877730 | 0.88 | MCHR1 (0.41) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6868723 | 0.86 | MCHR1 (0.40) | NPC1RAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL6878669 | 0.86 | SMN1; SMN2 (0.54) | NPC1RAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL6868714 | 0.86 | MCHR1 (0.40) | NPC1RAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL6878673 | 0.86 | SMN1; SMN2 (0.54) | NPC1RAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL6458264 | 0.84 | MCHR1 (0.41) | HTTSMN1; SMN2MCHR1ADRA2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |