Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549264 | 0.94 | SNCA (0.44) | NISCHTRPV1MEN1KMT2AKDM4E | |
| SCHEMBL6874639 | 0.90 | NISCH (0.42) | NISCHMEN1KMT2AKDM4EMAPT | |
| SCHEMBL6874632 | 0.90 | NISCH (0.42) | NISCHMEN1KMT2AKDM4EMAPT | |
| SCHEMBL548452 | 0.85 | NISCH (0.38) | NISCHTRPV1KDM4EALDH1A1 | |
| SCHEMBL549262 | 0.84 | NISCH (0.41) | NISCHMEN1KMT2AKDM4EMAPT | |
| SCHEMBL549263 | 0.84 | NISCH (0.41) | NISCHMEN1KMT2AKDM4EMAPT | |
| SCHEMBL548368 | 0.84 | AAK1 (0.40) | NISCHTRPV1MEN1KMT2AKDM4E | |
| SCHEMBL5307580 | 0.80 | RAB9A (0.60) | NISCHMEN1KMT2AKDM4EMAPT | |
| SCHEMBL548423 | 0.79 | KMT2A (0.50) | NISCHMEN1KMT2AKDM4EMAPT | |
| SCHEMBL548480 | 0.79 | F10 (0.46) | NISCHMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6815461-B1 | ADMINISTERING BIS-BENZIMIDAZOLE COMPOUND; TREATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2004-11-09 | — | — | US | disclosed |
| EP-0739202-B1 | USE OF BIS(AMIDINOBENZIMIDAZOLES) IN THE MANUFACTURE OF MEDICAMENT FOR INHIBITING RETROVIRAL INTEGRASE | UNIV NORTH CAROLINA (US) | 1998-12-16 | — | — | EP | disclosed |