Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874714 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6873498 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6462999 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6875398 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6876395 | 0.86 | MCHR1 (0.40) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6873401 | 0.86 | MCHR1 (0.40) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6868464 | 0.85 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6463054 | 0.85 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RDRD2CYP3A4 | |
| SCHEMBL6878836 | 0.84 | MCHR1 (0.57) | MCHR1ADRA2ANPY5RDRD2CYP2C9 | |
| SCHEMBL6875950 | 0.84 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RDRD2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |