Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.58 |
| ▸ | DHFR | P00374 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557380 | 0.95 | NTRK1 (0.64) | NTRK1CSF1RNTRK3NTRK2DHFR | |
| SCHEMBL6555293 | 0.92 | DHFR (0.60) | NTRK1CSF1RNTRK3NTRK2DHFR | |
| SCHEMBL6556791 | 0.87 | DHFR (0.66) | NTRK1CSF1RNTRK3NTRK2DHFR | |
| SCHEMBL6555466 | 0.87 | NTRK1 (0.53) | NTRK1CSF1RNTRK3NTRK2DHFR | |
| SCHEMBL6556403 | 0.86 | DHFR (0.55) | DHFR | |
| SCHEMBL6557379 | 0.84 | DHFR (0.58) | NTRK1CSF1RNTRK3NTRK2DHFR | |
| SCHEMBL6555352 | 0.84 | DHFR (0.57) | DHFR | |
| SCHEMBL6555245 | 0.84 | DHFR (0.55) | DHFR | |
| SCHEMBL6556707 | 0.84 | DHFR (0.53) | DHFR | |
| SCHEMBL6555407 | 0.83 | DHFR (0.57) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821980-B1 | Substituted 5-benzyl-2,4-diaminopyrimidines | BASILEA PHARMACEUTICA AG (CH) | 2004-11-23 | — | — | US | disclosed |