Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.49 |
| ▸ | HTR2B | P41595 | 6/20 | 0.49 |
| ▸ | HRH1 | P35367 | 5/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875273 | 1.00 | MCHR1 (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6877438 | 0.86 | CARM1 (0.49) | MCHR1ADRA2ACARM1PRMT6CCNT1 | |
| SCHEMBL6877434 | 0.86 | CARM1 (0.49) | MCHR1ADRA2ACARM1PRMT6CCNT1 | |
| SCHEMBL13795469 | 0.83 | MCHR1 (0.67) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6874488 | 0.83 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6874493 | 0.83 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6873929 | 0.83 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6873926 | 0.83 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6877508 | 0.81 | MCHR1 (0.59) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6877502 | 0.81 | MCHR1 (0.59) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |