Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874044 | 0.86 | AURKA (0.50) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL6874037 | 0.86 | AURKA (0.50) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL6457914 | 0.85 | CCR1 (0.43) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL6457922 | 0.85 | CCR1 (0.43) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL6880608 | 0.84 | LMNA (0.41) | HTTMAPK8MAPK9MAPK10CCNE1 | |
| SCHEMBL6880601 | 0.84 | LMNA (0.41) | HTTMAPK8MAPK9MAPK10CCNE1 | |
| SCHEMBL6877124 | 0.83 | EPHX2 (0.47) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL6461492 | 0.83 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CCNE1CDK2 | |
| SCHEMBL6455514 | 0.83 | LMNA (0.50) | HTTCYP3A4HPGDCYP2C19RAB9A | |
| SCHEMBL6461498 | 0.83 | MAPK8 (0.42) | MAPK8MAPK9MAPK10CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |