Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873666 | 0.90 | MCHR1 (0.51) | EPHX1EPHX2SMN1; SMN2TP53NFKB1 | |
| SCHEMBL6873659 | 0.90 | MCHR1 (0.51) | EPHX1EPHX2SMN1; SMN2TP53NFKB1 | |
| SCHEMBL6458798 | 0.89 | NPC1 (0.51) | EPHX1EPHX2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6876946 | 0.89 | EPHX1 (0.57) | EPHX1EPHX2MAPTPOLBADRA2A | |
| SCHEMBL6458790 | 0.89 | NPC1 (0.51) | EPHX1EPHX2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6878669 | 0.89 | SMN1; SMN2 (0.54) | EPHX1EPHX2SMN1; SMN2TP53NFKB1 | |
| SCHEMBL6878673 | 0.89 | SMN1; SMN2 (0.54) | EPHX1EPHX2SMN1; SMN2TP53NFKB1 | |
| SCHEMBL6880820 | 0.89 | EPHX1 (0.50) | EPHX1EPHX2MAPTADRA2AHRH1 | |
| SCHEMBL6880815 | 0.89 | EPHX1 (0.50) | EPHX1EPHX2MAPTADRA2AHRH1 | |
| SCHEMBL6875456 | 0.89 | EPHX1 (0.50) | EPHX1EPHX2ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |