Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875350 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2AHTTNPC1POLB | |
| SCHEMBL6458714 | 0.91 | MCHR1 (0.45) | MCHR1ADRA2AHTTHRH1HTR2B | |
| SCHEMBL6464517 | 0.91 | MCHR1 (0.45) | MCHR1ADRA2AHTTPOLBALDH1A1 | |
| SCHEMBL6462309 | 0.91 | MCHR1 (0.45) | MCHR1ADRA2AHTTHRH1HTR2B | |
| SCHEMBL6464523 | 0.91 | MCHR1 (0.45) | MCHR1ADRA2AHTTPOLBALDH1A1 | |
| SCHEMBL6868709 | 0.91 | NPC1 (0.53) | MCHR1ADRA2ANPC1POLBRAB9A | |
| SCHEMBL6868705 | 0.91 | NPC1 (0.53) | MCHR1ADRA2ANPC1POLBRAB9A | |
| SCHEMBL6878772 | 0.90 | MCHR1 (0.40) | MCHR1ADRA2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6878777 | 0.90 | MCHR1 (0.40) | MCHR1ADRA2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6459674 | 0.90 | HTT (0.58) | MCHR1ADRA2AHTTRAB9AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |