Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.64 |
| ▸ | HRH1 | P35367 | 4/20 | 0.64 |
| ▸ | HTR2B | P41595 | 3/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875382 | 1.00 | MCHR1 (0.64) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464646 | 0.92 | MCHR1 (0.62) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464648 | 0.92 | MCHR1 (0.62) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL7037175 | 0.92 | MCHR1 (0.63) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL7037171 | 0.92 | MCHR1 (0.63) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874704 | 0.90 | MCHR1 (0.66) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875655 | 0.90 | CNR1 (0.64) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874707 | 0.90 | MCHR1 (0.66) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875663 | 0.90 | CNR1 (0.64) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6873457 | 0.89 | MCHR1 (0.59) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |