Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875405 | 1.00 | KMT2A (0.46) | KMT2ARAB9AMAPTMEN1NPC1 | |
| SCHEMBL6868349 | 0.92 | MEN1 (0.44) | KMT2ARAB9AMAPTMEN1NPC1 | |
| SCHEMBL6868342 | 0.92 | MEN1 (0.44) | KMT2ARAB9AMAPTMEN1NPC1 | |
| SCHEMBL6868383 | 0.86 | MCHR1 (0.40) | KMT2ARAB9AMAPTMEN1MCHR1 | |
| SCHEMBL6868389 | 0.86 | MCHR1 (0.40) | KMT2ARAB9AMAPTMEN1MCHR1 | |
| SCHEMBL6876650 | 0.86 | MCHR1 (0.44) | KMT2AMCHR1ADRA2AEPHX2EPHX1 | |
| SCHEMBL6876661 | 0.86 | MCHR1 (0.44) | KMT2AMCHR1ADRA2AEPHX2EPHX1 | |
| SCHEMBL6877545 | 0.86 | NPC1 (0.56) | KMT2ARAB9AMAPTMEN1NPC1 | |
| SCHEMBL6877551 | 0.86 | NPC1 (0.56) | KMT2ARAB9AMAPTMEN1NPC1 | |
| SCHEMBL6875135 | 0.86 | MCHR1 (0.41) | KMT2ARAB9AMAPTMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |