Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | DDX3X | O00571 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877551 | 1.00 | NPC1 (0.56) | NPC1RAB9AADRA2AMCHR1EPHX2 | |
| SCHEMBL6875822 | 0.91 | PKM (0.54) | NPC1RAB9AADRA2AMCHR1KMT2A | |
| SCHEMBL6875814 | 0.91 | PKM (0.54) | NPC1RAB9AADRA2AMCHR1KMT2A | |
| SCHEMBL7109737 | 0.87 | NPC1 (0.54) | NPC1RAB9AADRA2AMCHR1EPHX2 | |
| SCHEMBL7109740 | 0.87 | NPC1 (0.54) | NPC1RAB9AADRA2AMCHR1EPHX2 | |
| SCHEMBL6867680 | 0.86 | ADRA2A (0.47) | NPC1RAB9AADRA2AMCHR1KMT2A | |
| SCHEMBL6873000 | 0.86 | MCHR1 (0.47) | NPC1RAB9AADRA2AMCHR1KMT2A | |
| SCHEMBL6873005 | 0.86 | MCHR1 (0.47) | NPC1RAB9AADRA2AMCHR1KMT2A | |
| SCHEMBL6875402 | 0.86 | KMT2A (0.46) | NPC1RAB9AADRA2AMCHR1EPHX2 | |
| SCHEMBL6875405 | 0.86 | KMT2A (0.46) | NPC1RAB9AADRA2AMCHR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |