Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 18/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 14/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875410 | 1.00 | MCHR1 (0.51) | MCHR1ADRA2ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6866568 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6866562 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6875781 | 0.88 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875770 | 0.88 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874530 | 0.86 | EPHX2 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874535 | 0.86 | EPHX2 (0.56) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877818 | 0.84 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877656 | 0.84 | MCHR1 (0.68) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6877822 | 0.84 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |