Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875597 | 1.00 | MCHR1 (0.42) | MCHR1NPC1MAPTTP53ADRA2A | |
| SCHEMBL6456764 | 0.91 | POLB (0.48) | MCHR1MAPTTP53ADRA2AADRA1A | |
| SCHEMBL6456777 | 0.91 | POLB (0.48) | MCHR1MAPTTP53ADRA2AADRA1A | |
| SCHEMBL6456447 | 0.91 | EPHX2 (0.43) | MCHR1NPC1ADRA2AADRA1AHTR2B | |
| SCHEMBL6456440 | 0.91 | EPHX2 (0.43) | MCHR1NPC1ADRA2AADRA1AHTR2B | |
| SCHEMBL7041689 | 0.88 | MCHR1 (0.43) | MCHR1NPC1ADRA2AADRA1AHTR2B | |
| SCHEMBL6876282 | 0.87 | MCHR1 (0.55) | MCHR1MAPTTP53ADRA2AADRA1A | |
| SCHEMBL6876273 | 0.87 | MCHR1 (0.55) | MCHR1MAPTTP53ADRA2AADRA1A | |
| SCHEMBL6873183 | 0.86 | MAPT (0.43) | MCHR1MAPTTP53ADRA2AADRA1A | |
| SCHEMBL6873188 | 0.86 | MAPT (0.43) | MCHR1MAPTTP53ADRA2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |