Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873183 | 1.00 | MAPT (0.43) | MAPTTP53MCHR1ADRA2AADRA1A | |
| SCHEMBL6873448 | 0.91 | MEN1 (0.48) | MAPTTP53MCHR1ADRA2ACNR1 | |
| SCHEMBL6873456 | 0.91 | MEN1 (0.48) | MAPTTP53MCHR1ADRA2ACNR1 | |
| SCHEMBL6873945 | 0.89 | MCHR1 (0.44) | MAPTTP53MCHR1ADRA2AADRA1A | |
| SCHEMBL6457972 | 0.89 | MCHR1 (0.44) | MAPTTP53MCHR1ADRA2AADRA1A | |
| SCHEMBL6456440 | 0.88 | EPHX2 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6456447 | 0.88 | EPHX2 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875603 | 0.86 | MCHR1 (0.42) | MAPTTP53MCHR1ADRA2AADRA1A | |
| SCHEMBL6875597 | 0.86 | MCHR1 (0.42) | MAPTTP53MCHR1ADRA2AADRA1A | |
| SCHEMBL6867254 | 0.84 | MCHR1 (0.48) | MAPTMCHR1ADRA2AADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |