Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.64 |
| ▸ | HTR2B | P41595 | 6/20 | 0.64 |
| ▸ | HRH1 | P35367 | 5/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875639 | 1.00 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6876045 | 0.90 | MCHR1 (0.66) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6876050 | 0.90 | MCHR1 (0.66) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6457233 | 0.89 | MCHR1 (0.59) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6880735 | 0.89 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6457240 | 0.89 | MCHR1 (0.59) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6880726 | 0.89 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6455382 | 0.88 | MCHR1 (0.74) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6455380 | 0.88 | MCHR1 (0.74) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6878712 | 0.88 | MCHR1 (0.62) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |