Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.62 |
| ▸ | HTR2B | P41595 | 7/20 | 0.62 |
| ▸ | HRH1 | P35367 | 6/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878703 | 1.00 | MCHR1 (0.62) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6869378 | 0.92 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6869383 | 0.92 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6455380 | 0.89 | MCHR1 (0.74) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6455382 | 0.89 | MCHR1 (0.74) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875639 | 0.88 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875646 | 0.88 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6876050 | 0.87 | MCHR1 (0.66) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6876045 | 0.87 | MCHR1 (0.66) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458399 | 0.86 | MCHR1 (0.73) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |