Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.43 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875970 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2AHTR2BHRH1RAB9A | |
| SCHEMBL6880291 | 0.90 | MCHR1 (0.45) | MCHR1ADRA2AHTR2BHRH1RAB9A | |
| SCHEMBL6880293 | 0.90 | MCHR1 (0.45) | MCHR1ADRA2AHTR2BHRH1RAB9A | |
| SCHEMBL6460846 | 0.90 | MEN1 (0.40) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868409 | 0.90 | MCHR1 (0.44) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6460838 | 0.90 | MEN1 (0.40) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6868412 | 0.90 | MCHR1 (0.44) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6874197 | 0.89 | RAB9A (0.54) | MCHR1ADRA2AHTR2BHRH1RAB9A | |
| SCHEMBL6460292 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2AHTR2BHRH1RAB9A | |
| SCHEMBL6874204 | 0.89 | RAB9A (0.54) | MCHR1ADRA2AHTR2BHRH1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |