Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875981 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6877690 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6877696 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6867536 | 0.87 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6877043 | 0.87 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6867532 | 0.87 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6877036 | 0.87 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6873131 | 0.86 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6873125 | 0.86 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 | |
| SCHEMBL6866954 | 0.85 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |