Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.48 |
| ▸ | MERTK | Q12866 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877696 | 1.00 | MCHR1 (0.48) | MCHR1MERTKADRA2ANPY5RMAPT | |
| SCHEMBL6873489 | 0.93 | MCHR1 (0.48) | MCHR1MERTKADRA2ANPY5RAPP | |
| SCHEMBL6873484 | 0.93 | MCHR1 (0.48) | MCHR1MERTKADRA2ANPY5RAPP | |
| SCHEMBL6875981 | 0.90 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RMAPTAPP | |
| SCHEMBL6875975 | 0.90 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RMAPTAPP | |
| SCHEMBL6877036 | 0.90 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RMAPTAPP | |
| SCHEMBL6867532 | 0.90 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RCXCR4VCP | |
| SCHEMBL6877043 | 0.90 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RMAPTAPP | |
| SCHEMBL6867536 | 0.90 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RCXCR4VCP | |
| SCHEMBL6874146 | 0.89 | MCHR1 (0.44) | MCHR1MERTKADRA2AMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |