Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 12/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686839 | 0.90 | PTGER3 (0.64) | PTGER3ALDH1A1KDM4E | |
| SCHEMBL687774 | 0.89 | PTGER3 (0.57) | PTGER3ALDH1A1TSHRHSD17B10ITGB1 | |
| SCHEMBL687884 | 0.85 | PTGER3 (0.42) | PTGER3ALDH1A1ITGB1ITGA4KDM4E | |
| SCHEMBL686984 | 0.84 | ALDH1A1 (0.55) | PTGER3ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL27587259 | 0.84 | ALDH1A1 (0.55) | PTGER3ALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL687440 | 0.81 | PTGER3 (0.55) | PTGER3ALDH1A1ITGB1ITGA4KDM4E | |
| SCHEMBL27741939 | 0.81 | ALDH1A1 (0.51) | PTGER3ALDH1A1TSHRHSD17B10ITGB1 | |
| SCHEMBL27741941 | 0.81 | ALDH1A1 (0.51) | PTGER3ALDH1A1TSHRHSD17B10ITGB1 | |
| SCHEMBL687885 | 0.80 | PTGER3 (0.40) | PTGER3ALDH1A1ITGB1ITGA4KDM4E | |
| SCHEMBL687721 | 0.79 | PTGER3 (0.62) | PTGER3ALDH1A1ITGB1ITGA4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |