Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.57 |
| ▸ | HTR2B | P41595 | 4/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.57 |
| ▸ | HRH1 | P35367 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872145 | 0.89 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6872150 | 0.89 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6874123 | 0.88 | MCHR1 (0.75) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6874129 | 0.88 | MCHR1 (0.75) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6877119 | 0.88 | MCHR1 (0.56) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6457674 | 0.88 | MCHR1 (0.57) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6457667 | 0.88 | MCHR1 (0.57) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6877116 | 0.88 | MCHR1 (0.56) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6867992 | 0.87 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BADRA1AHRH1 | |
| SCHEMBL6867985 | 0.87 | MCHR1 (0.69) | MCHR1ADRA2AHTR2BADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |