Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.45 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876186 | 1.00 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RCRHR1KDM4E | |
| SCHEMBL6874396 | 0.88 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RCRHR1KDM4E | |
| SCHEMBL6874392 | 0.88 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RCRHR1KDM4E | |
| SCHEMBL13797066 | 0.85 | MCHR1 (0.62) | MCHR1ADRA2ANPY5RHTR1AADRA1A | |
| SCHEMBL6878967 | 0.84 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6878960 | 0.84 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6874121 | 0.82 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6874117 | 0.82 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6872073 | 0.81 | NPY5R (0.45) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6872078 | 0.81 | NPY5R (0.45) | MCHR1ADRA2ANPY5RKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |