Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | IGSF11 | Q5DX21 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | LDLR | P01130 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876279 | 1.00 | OPRM1 (0.50) | OPRM1OPRL1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6880147 | 0.89 | MCHR1 (0.49) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL27652810 | 0.89 | MCHR1 (0.49) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6875053 | 0.85 | MCHR1 (0.49) | KDM4ELMNASMN1; SMN2MCHR1SMYD3 | |
| SCHEMBL6875056 | 0.85 | MCHR1 (0.49) | KDM4ELMNASMN1; SMN2MCHR1SMYD3 | |
| SCHEMBL6876994 | 0.85 | KDM4E (0.50) | KDM4EMCHR1HPGDALDH1A1ADRA2A | |
| SCHEMBL6877000 | 0.85 | KDM4E (0.50) | KDM4EMCHR1HPGDALDH1A1ADRA2A | |
| SCHEMBL6872998 | 0.84 | MCHR1 (0.51) | OPRM1OPRL1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6872993 | 0.84 | MCHR1 (0.51) | OPRM1OPRL1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6868813 | 0.83 | KDM4E (0.52) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |