Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 8/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687691 | 0.89 | PTGER3 (0.41) | CTSAPTGER3CYP26A1 | |
| SCHEMBL688035 | 0.87 | CTSA (0.41) | CTSAPTGER3KDM4EPOLBMAPT | |
| SCHEMBL688155 | 0.87 | PTGER3 (0.49) | CTSAPTGER3KDM4EPOLBMAPT | |
| SCHEMBL688040 | 0.87 | PTGER3 (0.49) | CTSAPTGER3KDM4EPOLBMAPT | |
| SCHEMBL687149 | 0.86 | CTSA (0.47) | CTSAPTGER3CYP26A1MAPT | |
| SCHEMBL688150 | 0.86 | ITGB1 (0.38) | CTSAPTGER3CYP26A1KEAP1NFE2L2 | |
| SCHEMBL688248 | 0.85 | POLB (0.39) | CTSACYP26A1KEAP1NFE2L2ITGB1 | |
| SCHEMBL687628 | 0.85 | KMT2A (0.42) | CTSAPTGER3CYP26A1KDM4EMAPT | |
| SCHEMBL687906 | 0.84 | PTGER3 (0.47) | CTSAPTGER3ITGB1ITGA4KDM4E | |
| SCHEMBL688413 | 0.84 | POLB (0.40) | CTSACYP26A1KEAP1NFE2L2ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |