Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876564 | 1.00 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6874877 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6874880 | 0.90 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6875826 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6875830 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6874906 | 0.87 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6874914 | 0.87 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RAPPKDM4E | |
| SCHEMBL6879043 | 0.86 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6879036 | 0.86 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RKDM4ELMNA | |
| SCHEMBL6867536 | 0.86 | MCHR1 (0.50) | MCHR1ADRA2ANPY5RAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |