Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 15/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.42 |
| ▸ | HRH1 | P35367 | 7/20 | 0.42 |
| ▸ | HTR2B | P41595 | 6/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876589 | 1.00 | KDM4E (0.46) | KDM4EGAACDK7CDK9MCHR1 | |
| SCHEMBL6880618 | 0.90 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880622 | 0.90 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6467272 | 0.82 | MCHR1 (0.40) | CDK7CDK9MCHR1ADRA2AHRH1 | |
| SCHEMBL6467267 | 0.82 | MCHR1 (0.40) | CDK7CDK9MCHR1ADRA2AHRH1 | |
| SCHEMBL13793609 | 0.80 | MCHR1 (0.58) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6868087 | 0.79 | KDM4E (0.44) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6868092 | 0.79 | KDM4E (0.44) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6880308 | 0.79 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880312 | 0.79 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |