Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663698 | 0.83 | MAOB (0.40) | MAOBCTSSCTSKKDM2BCHRM5 | |
| SCHEMBL4374422 | 0.83 | MAOB (0.40) | MAOBCTSSCTSKKDM2BCHRM5 | |
| SCHEMBL4374426 | 0.83 | MAOB (0.40) | MAOBCTSSCTSKKDM2BCHRM5 | |
| SCHEMBL9824792 | 0.81 | MAOB (0.39) | MAOBCTSSCTSKKDM2BCHRM5 | |
| SCHEMBL4374295 | 0.80 | MAOB (0.38) | MAOBCTSSCTSKKDM2BMAPT | |
| SCHEMBL4374291 | 0.80 | MAOB (0.38) | MAOBCTSSCTSKKDM2BCHRM5 | |
| SCHEMBL9824677 | 0.79 | MAPT (0.43) | MAOBCTSKCHRM5ADRA2CMAPT | |
| SCHEMBL9825161 | 0.79 | MAPT (0.47) | MAOBCTSKMAPT | |
| SCHEMBL13036986 | 0.79 | KDM2B (0.38) | MAOBKDM2BCHRM5CHRM2CHRM4 | |
| SCHEMBL3897140 | 0.79 | CYP2D6 (0.44) | MAOBKDM2BCHRM5DRD2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474420-A1 | QUINAZOLINE COMPOUNDS | Astrazeneca AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003064413-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | WO | disclosed |