Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824677 | 0.90 | MAPT (0.43) | MAOBMAPTCHRM5ADRA2CPOLB | |
| SCHEMBL9825161 | 0.87 | MAPT (0.47) | MAOBMAPTPOLBHRH3CTSK | |
| SCHEMBL9824752 | 0.83 | CHRM5 (0.53) | MAOBMAPTCHRM5ADRA2CHRH3 | |
| SCHEMBL9824457 | 0.83 | CHRM5 (0.53) | MAOBMAPTCHRM5ADRA2CHRH3 | |
| SCHEMBL663698 | 0.81 | MAOB (0.40) | MAOBCHRM5ADRA2CKDM2BCTSS | |
| SCHEMBL4374422 | 0.81 | MAOB (0.40) | MAOBCHRM5ADRA2CKDM2BCTSS | |
| SCHEMBL4374426 | 0.81 | MAOB (0.40) | MAOBCHRM5ADRA2CPOLBKDM2B | |
| SCHEMBL6876590 | 0.81 | MAOB (0.40) | MAOBMAPTCHRM5ADRA2CKDM2B | |
| SCHEMBL4374291 | 0.79 | MAOB (0.38) | MAOBMAPTCHRM5KDM2BCTSS | |
| SCHEMBL4374295 | 0.79 | MAOB (0.38) | MAOBMAPTKDM2BCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |