Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.44 |
| ▸ | ITGAV | P06756 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687498 | 0.96 | ALDH1A1 (0.42) | ITGB3ITGAVKMT2AMEN1POLB | |
| SCHEMBL687672 | 0.88 | CYP26A1 (0.43) | ALDH1A1PTGER3 | |
| SCHEMBL687418 | 0.87 | PTGER3 (0.46) | ALDH1A1PTGER3 | |
| SCHEMBL687428 | 0.87 | PTGER3 (0.56) | ITGB3ITGAVKMT2AMEN1ALDH1A1 | |
| SCHEMBL687886 | 0.87 | PTGER3 (0.56) | ITGB3ITGAVKMT2AMEN1ALDH1A1 | |
| SCHEMBL687411 | 0.87 | PTGER3 (0.42) | ALDH1A1PTGER3 | |
| SCHEMBL687520 | 0.86 | PTGER3 (0.42) | KMT2APOLBALDH1A1PTGER3 | |
| SCHEMBL688004 | 0.86 | PTGER3 (0.44) | KMT2AMEN1ALDH1A1PTGER3 | |
| SCHEMBL687155 | 0.86 | PTGER3 (0.44) | ALDH1A1PTGER3 | |
| SCHEMBL687771 | 0.86 | PTGER3 (0.45) | ALDH1A1PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |