Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876775 | 1.00 | MAPK8 (0.42) | MAPK8MAPK14MCHR1ADRA2AKDM4E | |
| SCHEMBL6461527 | 0.90 | MAPK8 (0.46) | MAPK8MAPK14MCHR1ADRA2AKDM4E | |
| SCHEMBL6461522 | 0.90 | MAPK8 (0.46) | MAPK8MAPK14MCHR1ADRA2AKDM4E | |
| SCHEMBL6868317 | 0.88 | MCHR1 (0.37) | MCHR1ADRA2AALDH1A1HRH1HTR2B | |
| SCHEMBL6868307 | 0.88 | MCHR1 (0.37) | MCHR1ADRA2AALDH1A1HRH1HTR2B | |
| SCHEMBL4034884 | 0.86 | MCHR1 (0.51) | MAPK8MAPK14MCHR1ADRA2AALDH1A1 | |
| SCHEMBL4034886 | 0.86 | MCHR1 (0.51) | MAPK8MAPK14MCHR1ADRA2AALDH1A1 | |
| SCHEMBL6880536 | 0.84 | ALOX12 (0.53) | MCHR1ADRA2AALDH1A1HRH1HTR2B | |
| SCHEMBL6880533 | 0.84 | ALOX12 (0.53) | MCHR1ADRA2AALDH1A1HRH1HTR2B | |
| SCHEMBL6876768 | 0.84 | NPSR1 (0.40) | MAPK8MAPK14MCHR1ADRA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |