Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876987 | 1.00 | ACHE (0.46) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6878788 | 0.91 | MCHR1 (0.39) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6878784 | 0.91 | MCHR1 (0.39) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6868799 | 0.90 | ACHE (0.46) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6868802 | 0.90 | ACHE (0.46) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6875802 | 0.89 | ACHE (0.48) | ACHEBACE1MCHR1DRD2CXCR4 | |
| SCHEMBL6875798 | 0.89 | ACHE (0.48) | ACHEBACE1MCHR1DRD2CXCR4 | |
| SCHEMBL6876983 | 0.88 | MCHR1 (0.45) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6874127 | 0.88 | MCHR1 (0.37) | ACHEBACE1MCHR1ADRA2AHTR2B | |
| SCHEMBL6457041 | 0.88 | MCHR1 (0.37) | ACHEBACE1MCHR1ADRA2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |