Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877107 | 1.00 | MCHR1 (0.43) | MCHR1KDRAURKBKMT2AADRA2A | |
| SCHEMBL6880721 | 0.94 | TP53 (0.46) | MCHR1KDRAURKBADRA2AHRH1 | |
| SCHEMBL6880714 | 0.94 | TP53 (0.46) | MCHR1KDRAURKBADRA2AHRH1 | |
| SCHEMBL6868958 | 0.92 | EPHX2 (0.42) | MCHR1KDRAURKBKMT2AADRA2A | |
| SCHEMBL6868955 | 0.92 | EPHX2 (0.42) | MCHR1KDRAURKBKMT2AADRA2A | |
| SCHEMBL6874218 | 0.89 | MCHR1 (0.41) | MCHR1KMT2AADRA2AHRH1HTR2B | |
| SCHEMBL6877414 | 0.89 | KMT2A (0.56) | MCHR1KDRAURKBKMT2AADRA2A | |
| SCHEMBL6874211 | 0.89 | MCHR1 (0.41) | MCHR1KMT2AADRA2AHRH1HTR2B | |
| SCHEMBL6877409 | 0.89 | KMT2A (0.56) | MCHR1KDRAURKBKMT2AADRA2A | |
| SCHEMBL6463172 | 0.88 | MCHR1 (0.43) | MCHR1KDRADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |