Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NMBR | P28336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868958 | 1.00 | EPHX2 (0.42) | EPHX2MCHR1KDRAURKBMAPK8 | |
| SCHEMBL6877107 | 0.92 | MCHR1 (0.43) | MCHR1KDRAURKBMAPK8MAPK9 | |
| SCHEMBL6877104 | 0.92 | MCHR1 (0.43) | MCHR1KDRAURKBMAPK8MAPK9 | |
| SCHEMBL6873242 | 0.90 | MCHR1 (0.37) | MCHR1MAPK8MAPK9MAPK10ADRA2A | |
| SCHEMBL6873247 | 0.90 | MCHR1 (0.37) | MCHR1MAPK8MAPK9MAPK10ADRA2A | |
| SCHEMBL6457210 | 0.90 | MCHR1 (0.40) | EPHX2MCHR1ADRA2AADRA1AHRH1 | |
| SCHEMBL6457203 | 0.90 | MCHR1 (0.40) | EPHX2MCHR1ADRA2AADRA1AHRH1 | |
| SCHEMBL6875772 | 0.89 | EPHX1 (0.44) | EPHX2MCHR1KDRAURKBADRA2A | |
| SCHEMBL6875782 | 0.89 | EPHX1 (0.44) | EPHX2MCHR1KDRAURKBADRA2A | |
| SCHEMBL6880721 | 0.88 | TP53 (0.46) | EPHX2MCHR1KDRAURKBADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |