Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877168 | 1.00 | TP53 (0.47) | TP53KDM4ESMN1; SMN2LMNAMCHR1 | |
| SCHEMBL6877259 | 0.91 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2LMNAMCHR1ADRA2A | |
| SCHEMBL6877266 | 0.91 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2LMNAMCHR1ADRA2A | |
| SCHEMBL6460801 | 0.91 | SMN1; SMN2 (0.43) | TP53KDM4ESMN1; SMN2LMNAMCHR1 | |
| SCHEMBL6873096 | 0.91 | KDM4E (0.43) | KDM4ESMN1; SMN2LMNAMCHR1ADRA2A | |
| SCHEMBL6874078 | 0.91 | MCHR1 (0.41) | TP53KDM4ESMN1; SMN2LMNAMCHR1 | |
| SCHEMBL6873091 | 0.91 | KDM4E (0.43) | KDM4ESMN1; SMN2LMNAMCHR1ADRA2A | |
| SCHEMBL6874083 | 0.91 | MCHR1 (0.41) | TP53KDM4ESMN1; SMN2LMNAMCHR1 | |
| SCHEMBL6458568 | 0.91 | SMN1; SMN2 (0.43) | TP53KDM4ESMN1; SMN2LMNAMCHR1 | |
| SCHEMBL6879363 | 0.91 | SMN1; SMN2 (0.46) | TP53KDM4ESMN1; SMN2LMNAMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |