Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.44 |
| ▸ | BCHE | P06276 | 5/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877209 | 1.00 | MCHR1 (0.49) | MCHR1ADRA2AACHEBCHEAPP | |
| SCHEMBL6866792 | 0.90 | MCHR1 (0.58) | MCHR1ADRA2AACHEBCHEAPP | |
| SCHEMBL6866791 | 0.90 | MCHR1 (0.58) | MCHR1ADRA2AACHEBCHEAPP | |
| SCHEMBL6876398 | 0.85 | MCHR1 (0.56) | MCHR1APPLMNASMN1; SMN2MEN1 | |
| SCHEMBL6876391 | 0.85 | MCHR1 (0.56) | MCHR1APPLMNASMN1; SMN2MEN1 | |
| SCHEMBL6874171 | 0.84 | MCHR1 (0.51) | MCHR1ADRA2AACHEBCHEAPP | |
| SCHEMBL6874173 | 0.84 | MCHR1 (0.51) | MCHR1ADRA2AACHEBCHEAPP | |
| SCHEMBL6873484 | 0.83 | MCHR1 (0.48) | MCHR1ADRA2AACHEBCHEAPP | |
| SCHEMBL6874033 | 0.83 | MCHR1 (0.54) | MCHR1ADRA2ASMN1; SMN2 | |
| SCHEMBL6874036 | 0.83 | MCHR1 (0.54) | MCHR1ADRA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |