Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877242 | 1.00 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL6877238 | 1.00 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL6851996 | 0.79 | CYP1A2 (0.47) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL6851990 | 0.79 | CYP1A2 (0.47) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL6851994 | 0.79 | CYP1A2 (0.47) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL6852332 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6852346 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6852339 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6847976 | 0.75 | KDM4E (0.60) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL6847982 | 0.75 | KDM4E (0.60) | KDM4ESMN1; SMN2ALDH1A1MAPTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |