Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.39 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852346 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1MAPK1NOTUMCHRNA7 | |
| SCHEMBL6852339 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1MAPK1NOTUMCHRNA7 | |
| SCHEMBL6876917 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1MAPK1NOTUMCHRNA7 | |
| SCHEMBL6851730 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1MAPK1NOTUMCHRNA7 | |
| SCHEMBL6879086 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6879082 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852285 | 0.79 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPK1PDK2LMNA | |
| SCHEMBL6880930 | 0.79 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPK1PDK2LMNA | |
| SCHEMBL6879079 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1MAPK1NOTUMPDK2 | |
| SCHEMBL6852283 | 0.79 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPK1PDK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |