Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877277 | 1.00 | MCHR1 (0.48) | MCHR1HPGDRAB9AMEN1ALDH1A1 | |
| SCHEMBL6874524 | 0.88 | MCHR1 (0.47) | MCHR1HPGDRAB9ANPC1ADRA2A | |
| SCHEMBL6874532 | 0.88 | MCHR1 (0.47) | MCHR1HPGDRAB9ANPC1ADRA2A | |
| SCHEMBL6877785 | 0.87 | MCHR1 (0.46) | MCHR1HPGDRAB9AALDH1A1NPC1 | |
| SCHEMBL6877781 | 0.87 | MCHR1 (0.46) | MCHR1HPGDRAB9AALDH1A1NPC1 | |
| SCHEMBL6458843 | 0.87 | HPGD (0.48) | MCHR1HPGDRAB9AALDH1A1KMT2A | |
| SCHEMBL6458853 | 0.87 | HPGD (0.48) | MCHR1HPGDRAB9AALDH1A1KMT2A | |
| SCHEMBL6879865 | 0.86 | MCHR1 (0.57) | MCHR1RAB9AADRA2AHTR1AADRA1A | |
| SCHEMBL6879862 | 0.86 | MCHR1 (0.57) | MCHR1RAB9AADRA2AHTR1AADRA1A | |
| SCHEMBL6873692 | 0.85 | MCHR1 (0.49) | MCHR1HPGDRAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |