Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877333 | 1.00 | MCHR1 (0.40) | MCHR1KDM4ESMN1; SMN2LMNAMAPK8 | |
| SCHEMBL6875042 | 0.90 | KDM4E (0.43) | MCHR1KDM4ESMN1; SMN2LMNAMAPK8 | |
| SCHEMBL6875022 | 0.90 | KDM4E (0.43) | MCHR1KDM4ESMN1; SMN2LMNAMAPK8 | |
| SCHEMBL6872718 | 0.84 | ALOX12 (0.49) | MCHR1KDM4ESMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6872723 | 0.84 | ALOX12 (0.49) | MCHR1KDM4ESMN1; SMN2LMNAMAPK1 | |
| SCHEMBL4034886 | 0.84 | MCHR1 (0.51) | MCHR1MAPK8MAPK14CYP1A2CYP3A4 | |
| SCHEMBL4034884 | 0.84 | MCHR1 (0.51) | MCHR1MAPK8MAPK14CYP1A2CYP3A4 | |
| SCHEMBL6458384 | 0.83 | SMN1; SMN2 (0.46) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A | |
| SCHEMBL6458375 | 0.83 | SMN1; SMN2 (0.46) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A | |
| SCHEMBL6459146 | 0.81 | SMN1; SMN2 (0.44) | MCHR1KDM4ESMN1; SMN2LMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |