Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877474 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RKCNH2CYP2D6 | |
| SCHEMBL6873945 | 0.91 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6457972 | 0.91 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6875024 | 0.91 | MCHR1 (0.53) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6875028 | 0.91 | MCHR1 (0.53) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6880426 | 0.91 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6880420 | 0.91 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6878131 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6878137 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RHTR2BADRA1A | |
| SCHEMBL6872909 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RHTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |