Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880420 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6879769 | 0.93 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6879762 | 0.93 | MCHR1 (0.47) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6877474 | 0.91 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RHRH1HTR2B | |
| SCHEMBL6873945 | 0.91 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6877468 | 0.91 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RHRH1HTR2B | |
| SCHEMBL6457972 | 0.91 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6875024 | 0.90 | MCHR1 (0.53) | MCHR1ADRA2ANPY5RMAPTSMN1; SMN2 | |
| SCHEMBL6875028 | 0.90 | MCHR1 (0.53) | MCHR1ADRA2ANPY5RMAPTSMN1; SMN2 | |
| SCHEMBL6878131 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |