Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877566 | 1.00 | RXFP1 (0.45) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL6880627 | 0.93 | RXFP1 (0.49) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL6880619 | 0.93 | RXFP1 (0.49) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL7039512 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL7039508 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877624 | 0.90 | GAA (0.51) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL6877615 | 0.90 | GAA (0.51) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL6877850 | 0.90 | EPHX1 (0.49) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL6877843 | 0.90 | EPHX1 (0.49) | RXFP1SMN1; SMN2TP53KDM4ELMNA | |
| SCHEMBL6460357 | 0.90 | EPHX1 (0.55) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |