Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039512 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRALDH1A1MCHR1ADRA2A | |
| SCHEMBL6462318 | 0.93 | RAB9A (0.50) | SMN1; SMN2TSHRMCHR1ADRA2AEPHX2 | |
| SCHEMBL6462316 | 0.93 | RAB9A (0.50) | SMN1; SMN2TSHRMCHR1ADRA2AEPHX2 | |
| SCHEMBL6877566 | 0.91 | RXFP1 (0.45) | SMN1; SMN2TSHRMCHR1ADRA2ALMNA | |
| SCHEMBL6877576 | 0.91 | RXFP1 (0.45) | SMN1; SMN2TSHRMCHR1ADRA2ALMNA | |
| SCHEMBL6873339 | 0.90 | ALDH1A1 (0.58) | SMN1; SMN2TSHRALDH1A1MCHR1ADRA2A | |
| SCHEMBL6873332 | 0.90 | ALDH1A1 (0.58) | SMN1; SMN2TSHRALDH1A1MCHR1ADRA2A | |
| SCHEMBL6867931 | 0.89 | TP53 (0.46) | SMN1; SMN2TSHRMCHR1ADRA2ANPC1 | |
| SCHEMBL6867927 | 0.89 | TP53 (0.46) | SMN1; SMN2TSHRMCHR1ADRA2ANPC1 | |
| SCHEMBL6880627 | 0.88 | RXFP1 (0.49) | SMN1; SMN2MCHR1ADRA2AEPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |