Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877772 | 1.00 | MCHR1 (0.50) | MCHR1ADRA2ATACR1ALDH1A1MDM2 | |
| SCHEMBL6874467 | 0.93 | MCHR1 (0.50) | MCHR1ADRA2AALDH1A1MEN1KMT2A | |
| SCHEMBL6874473 | 0.93 | MCHR1 (0.50) | MCHR1ADRA2AALDH1A1MEN1KMT2A | |
| SCHEMBL6879011 | 0.91 | MCHR1 (0.51) | MCHR1ADRA2AALDH1A1APPBCHE | |
| SCHEMBL6879016 | 0.91 | MCHR1 (0.51) | MCHR1ADRA2AALDH1A1APPBCHE | |
| SCHEMBL6873885 | 0.89 | MCHR1 (0.46) | MCHR1ADRA2AALDH1A1MDM2APP | |
| SCHEMBL6873877 | 0.89 | MCHR1 (0.46) | MCHR1ADRA2AALDH1A1MDM2APP | |
| SCHEMBL6873630 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2AAPPBCHEACHE | |
| SCHEMBL6873635 | 0.89 | MCHR1 (0.51) | MCHR1ADRA2AAPPBCHEACHE | |
| SCHEMBL6873798 | 0.88 | SIGMAR1 (0.54) | MCHR1ADRA2AMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |