Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877977 | 0.89 | HPGD (0.52) | MCHR1SIGMAR1NPY5RADRA2AKDM4E | |
| SCHEMBL6877973 | 0.89 | HPGD (0.52) | MCHR1SIGMAR1NPY5RADRA2AKDM4E | |
| SCHEMBL6877968 | 0.89 | HPGD (0.52) | MCHR1SIGMAR1NPY5RADRA2AKDM4E | |
| SCHEMBL6878610 | 0.86 | MCHR1 (0.48) | MCHR1NPY5RADRA2AKDM4ELMNA | |
| SCHEMBL6878604 | 0.86 | MCHR1 (0.48) | MCHR1NPY5RADRA2AKDM4ELMNA | |
| SCHEMBL13793205 | 0.83 | MCHR1 (0.56) | MCHR1NPY5RADRA2A | |
| SCHEMBL6879382 | 0.82 | MCHR1 (0.47) | MCHR1ALDH1A1NPY5RADRA2AKDM4E | |
| SCHEMBL6879386 | 0.82 | MCHR1 (0.47) | MCHR1ALDH1A1NPY5RADRA2AKDM4E | |
| SCHEMBL6867497 | 0.82 | MCHR1 (0.41) | MCHR1ALDH1A1NPY5RADRA2AKDM4E | |
| SCHEMBL6867504 | 0.82 | MCHR1 (0.41) | MCHR1ALDH1A1NPY5RADRA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |