Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879386 | 1.00 | MCHR1 (0.47) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6880494 | 0.94 | ALDH1A1 (0.48) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6873540 | 0.94 | NPY5R (0.49) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6873544 | 0.94 | NPY5R (0.49) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6880489 | 0.94 | ALDH1A1 (0.48) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6876952 | 0.92 | NPC1 (0.44) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6876960 | 0.92 | NPC1 (0.44) | MCHR1ROCK2ROCK1NPY5RADRA2A | |
| SCHEMBL6866972 | 0.91 | SIGMAR1 (0.44) | MCHR1NPY5RADRA2ANPC1SMN1; SMN2 | |
| SCHEMBL6866974 | 0.91 | SIGMAR1 (0.44) | MCHR1NPY5RADRA2ANPC1SMN1; SMN2 | |
| SCHEMBL6872998 | 0.89 | MCHR1 (0.51) | MCHR1NPY5RADRA2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |