Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877827 | 1.00 | ATM (0.39) | ATMHDAC1HDAC3HDAC2XDH | |
| SCHEMBL6877820 | 1.00 | ATM (0.39) | ATMHDAC1HDAC3HDAC2XDH | |
| SCHEMBL6879903 | 0.82 | HDAC1 (0.42) | HDAC1ERN1MAP4K4 | |
| SCHEMBL6879912 | 0.82 | HDAC1 (0.42) | HDAC1ERN1MAP4K4 | |
| SCHEMBL6879909 | 0.82 | HDAC1 (0.42) | HDAC1ERN1MAP4K4 | |
| SCHEMBL6877227 | 0.82 | MKNK1 (0.54) | CYP2A6MKNK1MKNK2 | |
| SCHEMBL6877229 | 0.82 | MKNK1 (0.54) | CYP2A6MKNK1MKNK2 | |
| SCHEMBL6877224 | 0.82 | MKNK1 (0.54) | CYP2A6MKNK1MKNK2 | |
| SCHEMBL6854141 | 0.79 | ATM (0.42) | ATMHDAC1HDAC3HDAC2XDH | |
| SCHEMBL6854146 | 0.79 | ATM (0.42) | ATMHDAC1HDAC3HDAC2XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |